Cavity-enhanced and spatial-multimode spin-wave-photon quantum interface

Practical realizations of quantum repeaters require quantum memory simultaneously providing high retrieval efficiency, long lifetime and multimode storages. So far, the combination of high retrieval efficiency and spatially multiplexed storages into a single memory remains challenging. Here, we set up a ring cavity that supports an array including 6 TEM00 modes and then demonstrated cavity enhanced and spatially multiplexed spin wave photon quantum interface (QI). The cavity arrangement is according to Fermat' optical theorem, which enables the six modes to experience the same optical length per round trip. Each mode includesn horizontal and vertical polarizations. Via DLCZ process in a cold atomic ensemble, we create non classically correlated pairs of spin waves and Stokes photons in the 12 modes. The retrieved fields from the multiplexed SWs are enhanced by the cavity and the average intrinsic retrieval efficiency reaches 70% at zero delay. The storage time for the case that cross-correlation function of the multiplexed QI is beyond 2 reaches 0.6ms

INEQUALITIES OF J-P-S-F TYPE

By means of the theory of majorization and under the proper hypotheses, the following inequalities of Jensen-Pečarić-Svrtan-Fan (Abbreviated as J-P-S-F) type are established

Integrated single-cell and bulk characterization of cuproptosis key regulator PDHB and association with tumor microenvironment infiltration in clear cell renal cell carcinoma

BackgroundRenal clear cell carcinoma (ccRCC) is one of the most prevalent cancers worldwide. Accumulating evidence revealed that copper-induced cell death played a vital role in various tumors. However, the underlying mechanism of cuproptosis with molecular heterogeneity and tumor microenvironment (TME) in ccRCC remains to be elucidated. The present study aimed to discover the biological function of cuproptosis regulators with the potential to guide clinical therapy.MethodsUsing Single-cell RNA-seq, bulk transcriptome and other multi-omics datasets, we identify essential cuproptosis-related hub gene PDHB for further study. The dysregulation of PDHB in ccRCC was characterized, together with survival outcomes, pathway enrichment and immune infiltration among tumor microenvironments. The functional significance and clinical association of PDHB was validated with loss of function experiments and surgical removal specimens.ResultsPDHB mRNA and protein expression level was significantly downregulated in ccRCC tissues compared with normal and paired normal tissues. Clinicopathological parameters and tissue microarray (TMA) indicated that PDHB was identified as a prognostic factor for survival outcomes among ccRCC patients. Additionally, low PDHB was negatively correlated with Treg cells, indicating an immunosuppressive microenvironment. Mechanistically, knockdown PDHB appeared to promote the RCC cells proliferation, migration, and invasion potentials. Subsequent studies showed that copper-induced cell death activation could overcome sunitinib resistance in RCC cells.ConclusionThis research illustrated a cuproptosis-related hub gene PDHB which could serve as a potential prognostic marker and provide therapeutic benefits for clinical treatment of ccRCC patients

Recognizing emotions induced by wearable haptic vibration using noninvasive electroencephalogram

The integration of haptic technology into affective computing has led to a new field known as affective haptics. Nonetheless, the mechanism underlying the interaction between haptics and emotions remains unclear. In this paper, we proposed a novel haptic pattern with adaptive vibration intensity and rhythm according to the volume, and applied it into the emotional experiment paradigm. To verify its superiority, the proposed haptic pattern was compared with an existing haptic pattern by combining them with conventional visual–auditory stimuli to induce emotions (joy, sadness, fear, and neutral), and the subjects’ EEG signals were collected simultaneously. The features of power spectral density (PSD), differential entropy (DE), differential asymmetry (DASM), and differential caudality (DCAU) were extracted, and the support vector machine (SVM) was utilized to recognize four target emotions. The results demonstrated that haptic stimuli enhanced the activity of the lateral temporal and prefrontal areas of the emotion-related brain regions. Moreover, the classification accuracy of the existing constant haptic pattern and the proposed adaptive haptic pattern increased by 7.71 and 8.60%, respectively. These findings indicate that flexible and varied haptic patterns can enhance immersion and fully stimulate target emotions, which are of great importance for wearable haptic interfaces and emotion communication through haptics

Correlation between hyperbilirubinemia risk and immune cell mitochondria parameters in neonates with jaundice

PurposeTo explore the correlation between mitochondria parameters of immune cells and hyperbilirubinemia risk in hospitalized neonates with jaundice.MethodsThis retrospective study included jaundiced neonates born between September 2020 and March 2022 at Shaoxing Keqiao Women & Children's Hospital. The neonates were divided into low, intermediate-low, intermediate-high, and high-risk groups according to the hyperbilirubinemia risk. The purpose parameters including percentage, absolute count, mitochondrial mass (MM), and single-cell MM (SCMM) of peripheral blood T lymphocytes detected by flow cytometry were collected.ResultsFinally, 162 neonates with jaundice (47, 41, 39, and 35 with low, intermediate-low, intermediate-high, and high-risk) were included. CD3+ SCMM was significantly higher in the high-risk group compared with the low and intermediate-low-risk groups (both P < 0.0083), CD4+ SCMM was significantly higher in the high-risk group compared with the three other groups (all P < 0.0083), and CD8+ SCMM was significantly higher in the intermediate-low and high-risk groups compared with the low-risk group (both P < 0.0083). CD3+ (r = 0.34, P < 0.001) and CD4+ (r = 0.20, P = 0.010) SCMM positively correlated with bilirubin levels.ConclusionsThe mitochondrial SCMM parameters differed significantly among jaundiced neonates with different hyperbilirubinemia risks. CD3+ and CD4+ T cell SCMM values were positively correlated with the serum bilirubin levels, and might correlated with hyperbilirubinemia risk

Role of melatonin in enhancing arbuscular mycorrhizal symbiosis and mitigating cold stress in perennial ryegrass (Lolium perenne L.)

Melatonin is a biomolecule that affects plant development and is involved in protecting plants from environmental stress. However, the mechanisms of melatonin’s impact on arbuscular mycorrhizal (AM) symbiosis and cold tolerance in plants are still unclear. In this research, AM fungi inoculation and exogenous melatonin (MT) were applied to perennial ryegrass (Lolium perenne L.) seedlings alone or in combination to investigate their effect on cold tolerance. The study was conducted in two parts. The initial trial examined two variables, AM inoculation, and cold stress, to investigate the involvement of the AM fungus Rhizophagus irregularis in endogenous melatonin accumulation and the transcriptional levels of its synthesis genes in the root system of perennial ryegrass under cold stress. The subsequent trial was designed as a three-factor analysis, encompassing AM inoculation, cold stress, and melatonin application, to explore the effects of exogenous melatonin application on plant growth, AM symbiosis, antioxidant activity, and protective molecules in perennial ryegrass subjected to cold stress. The results of the study showed that compared to non-mycorrhizal (NM) plants, cold stress promoted an increase in the accumulation of melatonin in the AM-colonized counterparts. Acetylserotonin methyltransferase (ASMT) catalyzed the final enzymatic reaction in melatonin production. Melatonin accumulation was associated with the level of expression of the genes, LpASMT1 and LpASMT3. Treatment with melatonin can improve the colonization of AM fungi in plants. Simultaneous utilization of AM inoculation and melatonin treatment enhanced the growth, antioxidant activity, and phenylalanine ammonia-lyase (PAL) activity, while simultaneously reducing polyphenol oxidase (PPO) activity and altering osmotic regulation in the roots. These effects are expected to aid in the mitigation of cold stress in Lolium perenne. Overall, melatonin treatment would help Lolium perenne to improve growth by promoting AM symbiosis, improving the accumulation of protective molecules, and triggering in antioxidant activity under cold stress

Discovery of potential biomarkers for osteoporosis using LC/GC−MS metabolomic methods

PurposeFor early diagnosis of osteoporosis (OP), plasma metabolomics of OP was studied by untargeted LC/GC−MS in a Chinese elderly population to find possible diagnostic biomarkers.MethodsA total of 379 Chinese community-dwelling older adults aged ≥65 years were recruited for this study. The BMD of the calcaneus was measured using quantitative ultrasound (QUS), and a T value ≤-2.5 was defined as OP. Twenty-nine men and 47 women with OP were screened, and 29 men and 36 women were matched according to age and BMI as normal controls using propensity matching. Plasma from these participants was first analyzed by untargeted LC/GC−MS, followed by FC and P values to screen for differential metabolites and heatmaps and box plots to differentiate metabolites between groups. Finally, metabolic pathway enrichment analysis of differential metabolites was performed based on KEGG, and pathways with P ≤ 0.05 were selected as enrichment pathways.ResultsWe screened metabolites with FC>1.2 or FC<1/1.2 and P<0.05 and found 33 differential metabolites in elderly men and 30 differential metabolites in elderly women that could be potential biomarkers for OP. 2-Aminomuconic acid semialdehyde (AUC=0.72, 95% CI 0.582-0.857, P=0.004) is highly likely to be a biomarker for screening OP in older men. Tetradecanedioic acid (AUC=0.70, 95% CI 0.575-0.818, P=0.004) is highly likely to be a biomarker for screening OP in older women.ConclusionThese findings can be applied to clinical work through further validation studies. This study also shows that metabolomic analysis has great potential for application in the early diagnosis and recurrence monitoring of OP in elderly individuals